Benjamin L. Moore

Bioinformatics PhD and Solutions Architect


I’m a Senior Bioinformatics Scientist at Illumina, based at their R&D site near Cambridge in the UK. Here I work on solutions to key informatics hurdles in the sequencing space, such as efficient and automated bioinformatics data analysis. I enjoy solving hard problems by writing quality software, preferably leveraging modern programming languages, agile development practices and effective cloud services.


2020- Illumina, Inc. Senior Bioinformatics Scientist (software engineer and solutions architect).

My work includes integrating Illumina’s best-in-class DRAGEN bioinformatics analysis pipelines with our flagship cloud platforms (BaseSpace Sequence Hub and Illumina Connected Analytics). I also develop public tools such as the BaseSpace Sequence Hub Commandline Interface, alongside many other internal software engineering projects ranging from bioinformatics scripts to web applications.

2015-20 Illumina, Inc. Bioinformatics Scientist (data scientist and statistical programmer).

I joined Illumina’s R&D organisation in 2015 where I worked on a wide range of bioinformatics and data science projects. Some public-facing work focused on variant comparison and analysis tooling, and I also advanced the popular Platinum Genomes gold-standard variant truthset by introducing novel validation methods.

Technical skills


2012-15 University of Edinburgh Bioinformatics PhD (supervisors: Colin Semple and Stuart Aitken). My thesis was titled Unravelling higher order chromatin organisation through statistical analysis and is available through the Edinburgh Research Archive.

2011-12 Imperial College London MSc Bioinformatics and Theoretical Systems Biology (Distinction)

2008-11 University of York BSc Biology (First class honours)


2021-24 AWS Certified Solutions Architect (Associate)

Areas of expertise


Journal articles

2019 Krusche P, Trigg L, Boutros PC, Mason CE, De La Vega FM, Moore BL et al. Best practices for benchmarking germline small-variant calls in human genomes. Nature Biotechnology, 37:555–56.

2017 Peluso S, Douglas A, Hill A, De Angelis C, Moore BL et al. Fibroblast growth factors (FGFs) prime the limb specific Shh enhancer for chromatin changes that balance histone acetylation mediated by E26 transformation-specific (ETS) factors. eLife, 6:e28590.

Eberle MA, Fritzilas E, Krusche P, Källberg M, Moore BL et al. A reference data set of 5.4 million phased human variants validated by genetic inheritance from sequencing a three-generation 17-member pedigree. Genome Research, 27:157-164.

2016 Yu N, Nützmann H-W, MacDonald JT, Moore B et al. Delineation of metabolic gene clusters in plant genomes by chromatin signatures. Nucleic Acids Research, 44(5):2255-2265.

Welch L, Brooksbank C, Schwartz R, Morgan SL, Gaeta B, Kilpatrick AM, Meitchen D, Moore BL et al. Applying, Evaluating and Refining Bioinformatics Core Competencies. PLoS Compututational Biology, 12(5): e1004943.

2015 Moore BL et al. Integrative modeling reveals the principles of multi-scale chromatin boundary formation in human nuclear organization. Genome Biology, 16:110.

Fraser J, Ferrai C, Chiariello AM, Schueler M, Rito T, Laudanno G, Barbieri M, Moore BL et al. Hierarchical folding and reorganization of chromosomes are linked to transcriptional changes in cellular differentiation. Molecular systems biology, 11:852.

2013 Moore BL et al. High–quality protein backbone reconstruction from alpha carbons using Gaussian mixture models. Journal of computational chemisty, 34(22):1881-9.

2011 Gardner PP, Daub J, Tate J, Moore BL et al. Rfam: Wikipedia, clans and the “decimal” release. Nucleic acids research, 39(S1):D141-5.

Book chapters

2017 Moore BL, Semple CA. Crossing Borders: Modeling Approaches to Understand Chromatin Domains and Their Boundaries. Epigenetics and Systems Biology, 3:45-67.


2014 Pieces in The Huffington Post (US): Here Are the Most Overrated and Underrated Movies of All Time; Celebrity Twitter Followers, by Gender (

2006– Articles for English Wikipedia: European Nucleotide Archive, RNA thermometer, Toxin-antitoxin system and more (



My personal github account hosts my hobby development projects as well as listing contributions to open source tools. Examples include: shiny apps blackspot and shinybrot, as well as an R package hosted by CRAN (mandelbrot).


I write a data science blog at where I apply R and Python to open datasets and write-up the results. My posts have been featured by sites including FiveThirtyEight, BuzzFeed, AVclub, io9 and more, and also led to being an invited blogger at the Huffington Post. My original wordpress blog ( has received over 150,000 unique visitors from 180 countries.


I co-founded a usergroup for the R programming language in Edinburgh called EdinbR. I helped to organise our monthly meetings and built our website: Our meetings attract 30-50 statisticians, data scientists and developers for talks and discussion about the R language and its applications. We’re sponsored by Revolution Analytics and have an organisational github account at


I entered Imperial College’s Summer Data Challenge competition, where entrants analysed a given dataset and then proposed a startup idea based on their results. I developed a modelling technique to select housing areas for investment and was awarded third place: £2,000 and startup support from Imperial Create Lab. My entry can be seen at and the code is shared on my github account.


MRC Capacity building scholarship (PhD fees + enhanced stipend)

MRC Full postgraduate scholarship (MSc fees + stipend)

ISCB computational biology Wikipedia competition 2013 (doi:10.1371/journal.pcbi.1003242; 2nd place)

Front cover design selected for J. Comp. Chem. (34:22) (doi:10.1002/jcc.23388)


2010-11 Wellcome Trust Sanger Institute (Cambridge, UK) Worked for two summers on the Rfam database ( in the Bateman group


Available on request.